I found this great TechNet article and wanted to share:
It’s a greatly described article about how to connect to each Office 365 service – MSOL itself, Exchange Online, Skype For Business, SharePoint Online and the Compliance Center.
If you go through the article, you can set up a script to prompt you once for Office 365 administrator credentials, and connect to each service for a one stop shop on managing your Office 365 environment from PowerShell.
One catch (which is mentioned in the article) is that you’ll need to run PowerShell in Administrator mode, or you won’t be able to import modules. You’ll see an error like:
The specified module 'Microsoft.Online.SharePoint.Online.PowerShell' was not loaded because no valid module file was found in any directory.
If you aren’t sure if you’re in Administrator or User mode, the default path prompted in the PowerShell window will be “PS C:\users\username>” for User mode, and “PS C:\Windows\system32>” for Administrator mode (along with the word “Administrator” in the PowerShell window title.
I’m only new to Office 365, but I’ve found the GUI via the web for user management rather basic – I can’t do simple tasks such as search for users on a specific domain, then add them to a group. PowerShell is absolutely necessary if you want to manage Office 365.